Studies on Chloride of Bone in Cat and Rat.

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Abstract
Observations on the Cl content of the bones of cats and rats revealed, in all but adult rats, that there was more Cl present than would be expected if the entire bone water content was extracellular fluid. This excess was constant at 1.53 meq/100 of fat-free dry bone in the cat over a wide range of water concentrations but, in rats, varied from a similar value in weanlings to the complete absence of an excess in 150 day old animals. No satisfactory hypothesis could be made concerning the location of this fraction of the total bone Cl. The accuracy of the Cl analysis was attested by the maximum variation of 1% between titrometric determinations of Cl and determinations using Br[degree]2. studies with Cr51 revealed that the blood content of well cleaned bone samples contributes less than 5% of the observed Cl and less than 10% of the observed water content.