The sedimentation characteristics of deoxyribonucleic acid from normal and diseased human tissues

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Abstract
Sedimentation-coefficient distribution curves at infinite dilution were determined for samples of deoxyribonucleic acid from human leucocytes and spleen. The distributions for preparations from normal leucocytes and non-leukemic spleen indicate that deoxyribonucleic acid exhibits tissue specificity. Differences exist between the distributions observed for deoxyribonucleic acid from normal leucocytes and from leucocytes of myeloid and lymphatic leukemia. In Brill-Simmers disease changes in the deoxyribonucleic acid of the spleen to a form which is found in the leucocytes in lymphatic leukemia can occur before the state at which lymphatic leukemia can be diagnosed clinically. The deoxyribonucleic acid of leucocytes from tuberculous empyema appears to be a randomly degraded form of that occurring in normal leucocytes.