Development of Renal Function in Fetal and Neo-Natal Rabbits Using Phenolsulfonphthalein.

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Abstract
Renal function in the rabbit as measured by phenolsulfonphthalein excretion increases rapidly and regularly in the first 10 days after birth but does not exist to an important degree before birth. At the end of 10 days of postnatal life the rate of dye excretion is 100 times greater than the prenatal rate while the renal mass is increased less than 20 fold. In one hr. PSP does not traverse the rabbit placenta in either direction in appreciable amts. after the 26th day of gestation. The effect of urethane anesthesia on the excretion of PSP by newborn rabbits was found to be negligible.

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