DETERMINATION OF PARTITION COEFFICIENTS FOR SEVERAL PROPRANOLOL ANALOGUES BY REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY

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Abstract
The partition coefficients, log P oct app, for a series of propranolol analogues have been obtained by reversed phase-high performance liquid chromatography (RP-HPLC). A Collander type equation was set for 22 different standards that have the same trend as their H-bond capability. Fluorinated propranolol analogues are known to possess enhanced pharmacological properties and thus they were also investigated according to their capability offorming H–bonding. It was found that these fluorinated analogues do behave differently from their H–substituted counterparts. The results suggest that this behaviour may not be related to the number of fluorine atoms in the side chain, but rather to the strong polarisation of the molecules.