COMPARATIVE PATHOGENESIS STUDIES WITH ONCOGENIC AND NON-ONCOGENIC MAREKS-DISEASE VIRUSES AND TURKEY HERPESVIRUS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 40  (4) , 541-548
Abstract
An apparently nononcogenic Marek''s disease virus (SB-1) and turkey herpesvirus could be readily isolated from spleen, bursa of Fabricius, thymus and peripheral blood lymphocytes of chickens beginning 4-6 days after inoculation, but unlike infections with 2 isolates of oncogenic Marek''s disease virus (JM-10 and CU-2), virus replication in these cells was rare and necrosis in the organs was essentially absent. Splenic enlargement was observed regularly during the first 4-11 days after inoculation and Marek''s disease tumor-associated surface antigen was observed on splenic and other lymphocytes in the 4 viral inoculation groups. Cellular cytotoxicity of splenic lymphocytes was demonstrated in vitro with culture Marek''s disease tumor cells (MSB-1 lymphoblastoid cell line) as the target in Cr-release assay. The 4 viral infections induced sensitized lymphocytes.