Phenylalanine and Tryptophan Scanning Mutagenesis of CYP3A4 Substrate Recognition Site Residues and Effect on Substrate Oxidation and Cooperativity
- 1 August 2001
- journal article
- research article
- Published by American Chemical Society (ACS) in Biochemistry
- Vol. 40 (34) , 10150-10160
- https://doi.org/10.1021/bi010758a
Abstract
No abstract availableKeywords
This publication has 6 references indexed in Scilit:
- A Kinetic Model for the Metabolic Interaction of Two Substrates at the Active Site of Cytochrome P450 3A4Published by Elsevier ,2001
- CYP3A4 drug interactions: correlation of 10 in vitro probe substratesBritish Journal of Clinical Pharmacology, 1999
- Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivativesBiochemical Journal, 1999
- Alanine-scanning Mutagenesis of a Putative Substrate Recognition Site in Human Cytochrome P450 3A4Journal of Biological Chemistry, 1997
- Differential Mechanisms of Cytochrome P450 Inhibition and Activation by α-NaphthoflavoneJournal of Biological Chemistry, 1997
- Diazepam metabolism by human liver microsomes is mediated by both S‐ mephenytoin hydroxylase and CYP3A isoforms.British Journal of Clinical Pharmacology, 1994