Measurement of "Extracellular Fluid Space" In Infants by Equilibration Technic Using Inulin and Sodium Ferrocyanide

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Abstract
A close correlation of "extracellular fluid volume" as measured at equilibration and after collection of totally excreted inulin and Na ferrocyanide was obtained in infants (after intraven. admn. of 1% and 0.01%, respectively, in 5% glucose soln.),thus shortening considerably the time needed for the determination. The ratios between the Na ferrocyanide and inulin spaces were 0.96 to 1.04. Na ferrocyanide equilibrated in a much shorter time than did inulin (45 min. vs. 2 hrs.). The comparative rate of glomerular filtration as measured by inulin and sodium ferrocyanide suggests tubular reabsorption of the latter substance in infants. No evidence of urinary disturbance was found in the infants given Na ferrocyanide.

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