Sequence of human haptoglobin cDNA: evidence that the α and β subunits are coded by the same mRNA
Open Access
- 1 January 1983
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 11 (17) , 5811-5819
- https://doi.org/10.1093/nar/11.17.5811
Abstract
We have isolated and sequenced a cDNA clone coding for human haptoglobin. Our sequence shows that haptoglobin is very likely synthesized as a single polypeptide chain which is then cleaved at an Axg residue to generate its two characteristic α and β subunits. Southern blot analysis suggests that there are at least two copies of the haptoglobin gene per haploid genome.Keywords
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