Controlled conjugation of nanoparticles with single stranded DNA
- 1 March 1999
- journal article
- Published by American Vacuum Society in Journal of Vacuum Science & Technology B: Microelectronics and Nanometer Structures
- Vol. 17 (2) , 494-496
- https://doi.org/10.1116/1.590583
Abstract
The controlled conjugation of Au nanoparticles using single-stranded DNA has been achieved by Watson–Crick base pairing interaction and a biotin-streptavidin reaction. Observation by atomic force microscopy have confirmed the one-to-one binding of Au nanoparticles to plasmid DNA. The results suggest that this method could be utilized to achieve nanoscale arrangements in a wide range of applications.Keywords
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