Structure to 1.9 Å resolution of a complex with herpes simplex virus type‐1 thymidine kinase of a novel, non‐substrate inhibitor: X‐ray crystallographic comparison with binding of aciclovir
Open Access
- 29 January 1999
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 443 (2) , 121-125
- https://doi.org/10.1016/s0014-5793(98)01619-6
Abstract
Treatment of herpes infections with nucleoside analogues requires as an initial step the activation of the compounds by thymidine kinase. As an aid to developing more effective chemotherapy, both for...Keywords
This publication has 20 references indexed in Scilit:
- The structures of thymidine kinase fromHerpes simplexvirus type 1 in complex with substrates and a substrate analogueProtein Science, 1997
- Effect of 9-(4-hydroxybutyl)-N2-phenylguanine (HBPG), a thymidine kinase inhibitor, on clinical recurrences of ocular herpetic keratitis in squirrel monkeysAntiviral Research, 1996
- 9-(4-hydroxybutyl)-N2-phenylguanine (HBPG), a thymidine kinase inhibitor, suppresses herpes virus reactivation in miceAntiviral Research, 1996
- Gene Therapy for Glioblastoma in Adult Patients: Safety and Efficacy Evaluation of an In Situ Injection of Recombinant Retroviruses Producing Cells Carrying the Thymidine Kinase Gene of the Herpes Simplex Type 1 Virus, to be Followed with the Administration of Ganciclovir. Laboratoire Immunologie B, Hôpital Pitié-Salpêtrière, Paris Cedex, FranceHuman Gene Therapy, 1996
- The three‐dimensional structure of thymidine kinase from Herpes simplex virus type 1FEBS Letters, 1995
- Synthesis, Properties, and Pharmacokinetic Studies of N2-Phenylguanine Derivatives as Inhibitors of Herpes Simplex Virus Thymidine KinasesJournal of Medicinal Chemistry, 1995
- The CCP4 suite: programs for protein crystallographyActa Crystallographica Section D-Biological Crystallography, 1994
- Free R value: a novel statistical quantity for assessing the accuracy of crystal structuresNature, 1992
- Improved methods for building protein models in electron density maps and the location of errors in these modelsActa Crystallographica Section A Foundations of Crystallography, 1991
- Purification and crystallization of thymidine kinase from herpes simplex virus type 1Journal of Molecular Biology, 1988