Teratogenic Changes in Early Chick Embryos Following Administration of Antitumor Agent. (Azaserine)

Publisher Website
Google Scholar
Abstract
The substituted serine O-diazoacetyl-L-serine (azaserine) produced teratogenic changes in chick embryos when inoculated over the blastoderms at 48 hours incubation. Such changes, observed on gross observation of harvested specimens within 24 hours after inoculation, consisted of general growth inhibition, general developmental retardation and specific retardation in the development of the encephalon, optic cup and lens vesicle. No gross changes were observed when control inoculations were made using saline or unsub-stituted L-serine. The possible application of this technique in the study of antitumor agents was discussed.