Characterization of the Hollow Fiber Assay for the Determination of Microtubule DisruptionIn vivo
- 1 October 2004
- journal article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 10 (19) , 6677-6685
- https://doi.org/10.1158/1078-0432.ccr-04-0855
Abstract
Purpose: The hollow fiber assay is used successfully as a routine in vivo screening model to quantitatively define anticancer activity by the National Cancer Institute. This study investigates whether the hollow fiber assay can be used as a short-term in vivo model to demonstrate specific pharmacodynamic end points, namely microtubule and cell cycle disruption.Keywords
This publication has 33 references indexed in Scilit:
- A potential role for imaging technology in anticancer efficacy evaluationsEuropean Journal Of Cancer, 2004
- In vivo drug screening applications of HIV-infected cells cultivated within hollow fibers in two physiologic compartments of miceAntiviral Research, 1995
- In vivo cultivation of tumor cells in hollow fibersLife Sciences, 1995
- Growth of tumor cells within microporous hollow fibers: An in vitro model system for studies of immunoprotein transportBiotechnology & Bioengineering, 1990
- Correlation of drug response in patients and in the clonogenic assay with solid human tumour xenograftsEuropean Journal of Cancer and Clinical Oncology, 1990
- Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4Cellular and Molecular Life Sciences, 1989
- Isolation, Structure, and Synthesis of Combretastatins A-1 and B-1, Potent New Inhibitors of Microtubule Assembly, Derived from Combretum caffrumJournal of Natural Products, 1987
- Taxol binds to polymerized tubulin in vitroThe Journal of cell biology, 1981
- Promotion of microtubule assembly in vitro by taxolNature, 1979
- Plant antitumor agents. VI. Isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifoliaJournal of the American Chemical Society, 1971