Influence of Adrenaline and Insulin on Adrenal Cortical Response to ACTH

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Abstract
To investigate the mechanism of the previously observed enhancement of the adrenal response to ACTH following the admn. of glucose, this response was studied in hypophysectomized animals under conditions of epinephrine hyperglycemia and insulin-induced hypoglycemia. Detns. were made of blood-sugar, plasma ascorbic acid, liver glycogen, adrenal cholesterol and ascorbic acid. The blood sugar changes resulting from epinephrine or insulin admn. were not influenced by ACTH. A marked fall in plasma ascorbic acid concn. resulted from the admn. of epinephrine and insulin either alone or in association with ACTH. Neither epinephrine nor insulin modified the response to ACTH of liver glycogen and of adrenal cholesterol and ascorbic acid. The effects of alimentary hyperglycemia are therefore attributed to an increase in the total store of carbohydrates or to an excess production of intermediary metabolites, which conditions are not duplicated by epinephrine.

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