A STANDARDIZED METHOD FOR THE PRODUCTION OF HEMORRHAGIC SHOCK IN THE RAT

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Abstract
A method resembling the reservoir technique developed by Wiggers and Werle (1942) for the dog using blood pressure as the criterion was modified for use with the rat In the standardization of this technique the blood pressure was reduced to 30 mm Hg in a 10-minute period of hemorrhage and then maintained at this level by subsequent small hemorrhages into the reservoir until reinfusion indicated the beginning of vascular collapse, at which time all the blood in the reservoir was returned. The mortality rate was 78%. During the hypotensive period there was a consistent and steady drop in the respiratory rate and rectal temperature. The heart rate declined initially and tended to recover as the hypotensive period progressed. After reinfusion the blood pressure rose but did not reach prehemorrhage levels. Hemorrhage into the bowel and convulsions were significant postreinfusion findings.

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