Inhibition de l'action phototoxique du bergaptène par des filtres UV-A

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Abstract
It is well known that 5-methoxypsoralen (5-MOP, bergaptene) exerts several biological actions on irradiation with long wavelength (UV-A, .lambda. > 320 nm) UV light. The phototoxic activity elicited in guinea pigs by topical application of 5-MOP followed by irradiation was evaluated to learn if it could be reduced or inhibited by the simultaneous application of substances which absorb in the UV-A region. The photosensitizing solutions were; an alcoholic solution of 5-MOP, diluted bergamot oil, and an experimental perfume. Of the filters tested, 2 dibenzoylmethane derivatives proved particularly effective. The inhibitory activity of the filters was significantly greater when these were co-administered with bergamot oil or with the perfume, with respect to the activity shown in the 5-MOP alcoholic solution. A distyrylbiphenyl derivative showing an absorption maximum at 350 nm, was particularly effective.