Characterization of two deletions that remove the entire human ζ‐α globin gene complex (—THAI and —FIL)
- 1 October 1988
- journal article
- research article
- Published by Wiley in British Journal of Haematology
- Vol. 70 (2) , 233-238
- https://doi.org/10.1111/j.1365-2141.1988.tb02469.x
Abstract
We have fully characterized two .alpha. thalassemia mutants that occur in Southeast Asia. --THAI and --FIL. Each mutant is due to a deletion that removes the entire .zeta.-.alpha.-globin gene complex. Localization of the 5'' breakpoints described here, allows the identification of unique fragments that are specific for each of the two mutations. This information can be used to assess the frequency of these mutants in Southeast Asia and will be of value in prenatal testing for .alpha. thalassemia in this area.This publication has 10 references indexed in Scilit:
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