Comparison of Techniques for Peak Purity Testing of Cephalosporins
- 1 December 1992
- journal article
- research article
- Published by Taylor & Francis in Journal of Liquid Chromatography
- Vol. 15 (17) , 3031-3043
- https://doi.org/10.1080/10826079208016368
Abstract
The efficiency of spectral suppression, absorbance ratio and spectral overlay for peak purity testing using a diode array detector has been compared on a strongly overlapping model systea (cefotaxime and theophylline). Spectral overlay and spectral suppression have a comparable sensitivity (0.3 % of impurity can be detected) spectral suppression allows an accurate determination of impurity at 1% level; absorbance ratio is the less powerful technique.Keywords
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