Effects of Parathyroid Hormone on Phosphate Turnover in Bone and Kidney

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Abstract
The effect of parathyroid hormone (PTH) on phosphate transport in bone cells and kidney tissue was studied using commercial PTH and P32O4. Newborn rats were injected intraperitoneally with 10 units of PTH 30 min prior to P32O4 injection. At 30 min, 1 hr, 1½ hr and 2 hr after P32 injection, the P32O4 content of the acid-soluble organic phosphate fraction of calvaria was higher in PTH-injected than in control animals. At 15 min, 45 min and 90 min after P32O4 injection, specific activity of the total renal phosphate was higher in PTH-injected rats than in controls despite similar blood disappearance curves in the 2 groups. Cortex showed a greater P32O4 uptake than medulla, but the relative increase caused by PTH was greater in medulla. These data suggest that PTH has some action on phosphate transport at the cellular level.