Genetic Polymorphism of C′3(β 1C -Globulin) in Human Serum
- 22 November 1968
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 162 (3856) , 905-907
- https://doi.org/10.1126/science.162.3856.905
Abstract
Genetic polymorphism of the third component of human complement and its breakdown products has been detected in human serum by high-voltage starch-gel electrophoresis. Six phenotypes were observed in a study of 113 randomly chosen Caucasians. Their inheritance is controlled by four codominant alleles at an autosomal locus. The gene frequencies in this study were C31, 0.21; C32, 0.77; C33, ∼0.01; and C34, ∼0.004.Keywords
This publication has 13 references indexed in Scilit:
- Genetic polymorphism of the third component of human complement (C′3)Journal of Clinical Investigation, 1968
- Chemistry and Reaction Mechanisms of ComplementPublished by Elsevier ,1968
- Synthesis of β1E and β1C Components of Complement in Human FoetusesActa Paediatrica, 1967
- Inborn Errors of the Complement System of ManNew England Journal of Medicine, 1967
- Genetically Determined Electrophoretic Variant of the Human Complement Component C′3Nature, 1967
- THE REACTION MECHANISM OF ß1C-GLOBULIN (C'3) IN IMMUNE HEMOLYSISThe Journal of Experimental Medicine, 1966
- RELATION OF A ß1-GLYCOPROTEIN OF HUMAN SERUM TO THE COMPLEMENT SYSTEMThe Journal of Experimental Medicine, 1960
- An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individualsBiochemical Journal, 1959
- Variations in Human Serum β-GlobulinsNature, 1957
- Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adultsBiochemical Journal, 1955