Kinetics of Nornicotine and Anabasine Nitrosation in Relation to N ′-Nitrosonornicotine Occurrence in Tobacco and to Tobacco-Induced Cancer 2
- 1 October 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 59 (4) , 1211-1213
- https://doi.org/10.1093/jnci/59.4.1211
Abstract
The kinetics of nornicotine and anabasine nitrosation, studied in aqueous solution, obeyed equations typical for the nitrosation of aliphatic secondary amines, with third-order stoichiometric rate constants of 1.15 (nornicotine) and 0.86 (anabasine) m−2 sec−1. The similarity of the two rate constants suggested that the nitrosonornicotine occurring in tobacco arises from nicotine rather than nornicotine, because tobacco contains anabasine but apparently does not contain nitrosoanabasine. The high rate constants suggested that in vivo nitrosation of these secondary amines may constitute a hazard to tobacco smokers and chewers, in addition to that presented by preformed nitrosonornicotine.Keywords
This publication has 1 reference indexed in Scilit:
- Origin in Tobacco Smoke of N ′-Nitrosonornicotine, a Tobacco-Specific Carcinogen: Brief Communication 2 3JNCI Journal of the National Cancer Institute, 1977