Effect of Dietary Protein Restriction on the Development of Renal Failure after Subtotal Nephrectomy in Rats

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Abstract
1. We have examined the effect of a low protein diet on the development of glomerular sclerosis and progressive renal failure after subtotal nephrectomies in rats. 2. Two groups of male Sprague-Dawley rats were studied after five-sixths nephrectomy; group 1 were maintained on a normal diet (13.5 g day−1 kg−1 body weight) and group 2 were fed with a low protein diet (6 g day−1 kg−1 body weight). 3. Rats maintained on a low protein diet survived for longer, and had significantly less glomerular sclerosis and significantly greater glomerular filtration rates when the experiment ended after 7 months. 4. We conclude that dietary protein influences favourably the development of glomerular scarring and renal failure after subtotal nephrectomy in rats.