Increasing Stimulation of Megakaryocytopoiesis with Decreasing Platelet Count

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Abstract
Rats were exchange transfused with platelet-poor blood to produce varying degrees of thrombocytopenia. Marrow samples were taken 31 hr later and the megakar-yocyte population was scored for the percentage in endomitosis. The MeI progressively increased as the circulating platelet count was reduced. These findings are consistent with the concept of a humoral regulator of thrombocytopoiesis, the activity of which is related to the severity of depression of circulating platelets.

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