Complement-Fixation in Experimental and Human Poliomyelitis.

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Abstract
Expts. are presented which show that complement-fixing antibodies can be dem onstrated in the blood of rats immunized with formalized Lansing virus, in convalescent monkey serum, and in some convalescent human sera, when conc. Lansing virus from cotton rats is used as antigen. The results with rat sera are com -plicated by the presence of antibodies against components of normal brain and spinal cord in both immune and normal animals, but the evidence indicates that the primary reaction with immune sera is between antibody and virus. Immunization as a result of injn. of formalized virus is, therefore, associated with the production of serologically detectable antibodies to active virus. The expts. with the convalescent monkey and human sera provide definite proof that positive complement-fixation can be demonstrated when conc. Lansing virus prepd. as previously described is used as the antigen. These results further support the importance of the Lansing virus or an antigenically related strain as one responsible for the human disease.

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