LIVER GLYCOGEN DEPOSITION AFTER INTRAVENOUS AND INTRAGASTRIC ADMINISTRATION OF CORTISOL-4-C14TO RATS1

Publisher Website
Google Scholar
Abstract
Liver glycogen deposition in fasting rats was measured following intravenous and intragastric administration of 3.0 mg cortisol-4-C14 per kg. Significant increases in glycogen content of the hormone-treated animals over controls occurred 3 hours after injection and 4 hours after gavage. Following intragastric administration of radiocortisol, a greater and more prolonged response was noted than that found after intravenous injection. Cortisol-4-C 14 or its radiometabolites disappeared from the liver approximately 1 hour before a significant increase in glycogen content took place and 2 or more hours before the maximum physiological response occurred. These experiments suggest that cortisol exerts a triggering action on the reaction sequence producing the deposition of glycogen.