The Synthesis of 2-Fluoropurine Nucleosides
- 1 March 1994
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 13 (1-3) , 673-678
- https://doi.org/10.1080/15257779408013271
Abstract
2-Aminoadenosine, obtained by silylation-amination from guanosine, is readily converted by KNO2/ HF/Pyridine in up to 80% yield into 2-fluoradenosine, which is a convenient starting material for the preparation of 9(β-D-arabinofuranosyl)-2-fluoroadenine 5′-phosphate (Fludara). N6N6-Pentamethylene-2-aminoadenosine and guanosine afford likewise the corresponding 2-fluoropurine nucleosides in high yields.Keywords
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