Local Anaesthetics Modifying the Dermal Response of Irradiation: An experimental study
- 1 January 1987
- journal article
- research article
- Published by Taylor & Francis in Acta Oncologica
- Vol. 26 (6) , 467-476
- https://doi.org/10.3109/02841868709113720
Abstract
In a series of experiments in rabbits the dermal reaction, provoked by a single dose or intermittent doses of irradiation, was prevented or modified by topical or parenteral administration of local anaesthetics, compared to irradiated control animals. The topical application of a eutectic lidocaine/prilocaine cream, EMLA 5%, was found to be more effective than intravenously injected lidocaine (Xylocain 1%).Keywords
This publication has 40 references indexed in Scilit:
- Free radicals in biology and medicineJournal of Free Radicals in Biology & Medicine, 1985
- LIDOCAINE CONSTRICTS OR DILATES RAT ARTERIOLES IN A DOSE-DEPENDENT MANNERAnesthesiology, 1984
- An Experimental Model to Determine the Level of Antibiotics in Irradiated TissuesPlastic and Reconstructive Surgery, 1984
- Hemodynamics after microsurgical anastomosis: The effects of topical lidocaineMicrosurgery, 1981
- Antithrombotic Effects of Lidocaine and Related Compounds on Laser‐Induced Microvascular InjuryActa Anaesthesiologica Scandinavica, 1981
- Release of Inflammatory Mediators from Stimulated NeutrophilsNew England Journal of Medicine, 1980
- INTRAVENOUS LIGNOCAINE IN PREVENTION OF DEEP VENOUS THROMBOSIS AFTER ELECTIVE HIP SURGERYThe Lancet, 1977
- THE ADHESION OF LEUKOCYTES, ERYTHROCYTES, AND NONCELLULAR MATERIAL TO THE LUMINAL SURFACE OF NATURAL AND ARTIFICIAL BLOOD VESSELS IN VIVOAnnals of the New York Academy of Sciences, 1977
- General anesthetics expand cell membranes at surgical concentrationsBiochimica et Biophysica Acta (BBA) - Biomembranes, 1972
- Plasma Lidocaine Concentrations After Caudal, Lumbar Epidural, Axillary Block, and Intravenous Regional AnesthesiaAnesthesiology, 1966