The relation of the rates of flocculation and amounts of precipitate in precipitin reactions to the concentration of hydrogen ion and of neutral salts.

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  • 1 July 1958
    • journal article
    • Vol. 1  (3) , 251-67
Abstract
The effects of concentration of hydrogen ion and of neutral salts on the amounts of precipitate and rates of flocculation have been studied with several antigen-antibody systems, in particular those of bovine serum albumin (BSA) and lysozyme (L) with their rabbit antibodies. In all the systems studied the amount of precipitate and rate of flocculation were maximum over a pH range extending on both sides of pH 7. The range of pH, over which the rate of flocculation was maximum, was narrower than the range over which the amount of precipitate was maximum; outside this range the rate of flocculation fell more steeply than the amount of precipitate.