Mucosal Administration of Flagellin Induces Innate Immunity in the Mouse Lung
Open Access
- 1 November 2004
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 72 (11) , 6676-6679
- https://doi.org/10.1128/iai.72.11.6676-6679.2004
Abstract
Nonsurgical intratracheal instillation of 1 μg of purified, recombinant flagellin in several strains of mice stimulated a transient innate immune response in the lung characterized by the infiltration of neutrophils and the rapid production of tumor necrosis factor alpha, interleukin 6, granulocyte colony-stimulating factor, and the chemokines keratinocyte-derived chemokine, MIP1α, and MIP-2.Keywords
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