Abstract
The rate of energy metabolism in the rabbit begins to rise on the 2nd day after stimulation of the cephalic end of the cut cervical sympathetic trunk. It reaches a maximum averaging, at 11 to 15 days, 29% above normal, and returns to normal in 41 to 60 days. Thyroidectomized rabbits subjected to the same stimulation do not show this rise. Severance without stimulation of the trunk has no appreciable effect upon the metabolic rate. Removal of the thyroid gland immediately following stimulation of the nerve trunk prevents the long-lasting rise in metabolic rate which is seen when the thyroid is left intact.

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