Participation of c- myc Protein in DNA Synthesis of Human Cells
- 24 October 1986
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 234 (4775) , 467-470
- https://doi.org/10.1126/science.3532322
Abstract
The protein product of oncogene c-myc is believed to be important in regulation of the cell cycle. However, its direct role in DNA synthesis has not been explored. Experiments presented here show that the addition of affinity-purified antibodies against the human c-myc protein to nuclei isolated from several types of human cells reversibly inhibited DNA synthesis and DNA polymerase activity of these nuclei. This suggests that c-myc encodes a protein that is functionally involved in DNA synthesis.This publication has 24 references indexed in Scilit:
- Changes in the expression of oncogenes encoding nuclear phosphoproteins but not c-Ha-ras have a relationship to monocytic differentiation of HL 60 cells.The Journal of cell biology, 1986
- The replication of adenovirus DNA with purified proteinsCell, 1983
- Proteins encoded by v-myc and c-myc oncogenes: Identification and localization in acute leukemia virus transformants and bursal lymphoma cell linesCell, 1983
- Specific chromosomal translocations and the genesis of B-cell-derived tumors in mice and menCell, 1983
- Aphidicolin prevents mitotic cell division by interfering with the activity of DNA polymerase-αNature, 1978
- Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-SepharoseImmunochemistry, 1978
- Deoxyribonucleic acid synthesis in isolated nuclei from chicken embryo fibroblast cell culturesBiochemistry, 1974
- Ribosomal RNA synthesis in isolated nucleiJournal of Molecular Biology, 1972
- Specific Inhibition of Nuclear RNA Polymerase II by α-AmanitinScience, 1970
- The synthesis and assembly of DNA subunits in isolated HeLa cell nucleiBiochemical and Biophysical Research Communications, 1969