Frameshift mutations induced by an Escherichia coli strain carrying a mutator gene, mutD5
- 1 November 1983
- journal article
- Published by Springer Nature in Molecular Genetics and Genomics
- Vol. 192 (3) , 515-516
- https://doi.org/10.1007/bf00392200
Abstract
We have studied eight frameshift mutations induced by the Escherichia coli mutator allele mutD5 in a derivative of the bacteriophage M13mp8, carrying an insertion of 91 base pairs derived from the tet R gene of pBR 322. All mutations were analyzed by the dideoxy sequencing method and were found to be deletions of a GC base pair which occurred in regions characterized by the presence of at least two GC base pairs. We have attempted to explain these results by the looping-out model, which was previously proposed to unify the results obtained with mutD5.Keywords
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