Effects of Gastrin and Pentagastrin on Gastric and Pancreatic Secretion in Dogs

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Abstract
Porcine gastrin and pentagastrin were compared as stimulants of gastric and pancreatic secretion in conscious dogs. The maximal acid output was greater and the dose response curve for acid output steeper in response to gastrin than to pentagastrin in the vagally innervated main stomach; these differences were not found in vagally denervated pouches. The shape of the dose response curve for pepsin output in response to gastrin and pentagastrin differed markedly. The maximal pepsin response to pentagastrin occurred with doses that were submaximal for acid secretion, in this respect resembling histamine. The slope of the dose response curve for protein output from the pancreas was steeper in response to gastrin than to pentagastrin whereas the curves for bicarbonate output were parallel. The maximal pancreatic output of protein or bicarbonate with gastrin and pentagastrin did not differ significantly. It is concluded that there are important differences between gastrin and pentagastrin in stimulation of gastric and pancreatic secretion.