INTERRELATIONSHIPS OF ERYTHROCYTE GLUTATHIONE PEROXIDASE SYSTEM ENZYMES IN FASTED BEAGLE

  • 1 January 1978
    • journal article
    • research article
    • Vol. 39  (2) , 267-270
Abstract
Eight adult female Beagles were fasted for 21 days to investigate responses of the erythrocyte glutathione peroxidase [EC 1.11.1.9] system enzymes. Blood samples were collected once a week. Erythrocytic reduced glutathione was maintained within 10% of base-line value. Hexose monophosphate pathway dehydrogenases showed a significant inverse relationship to glutathione reductase (GR) activity. Active GR, as a percentage of total GR, increased as hexose monophosphate pathway dehydrogenase activity fell. A similar relationship between these enzymes was reported in human glucose-6-phosphate dehydrogenase deficiency. Glutathione peroxidase showed an inverse linear response to erythrocytic reduced glutathione. Though the responses of this system are complex, they appear interrelated.