INTERLEUKIN-6 ENHANCES GROWTH FACTOR-DEPENDENT PROLIFERATION OF THE BLAST CELLS OF ACUTE MYELOBLASTIC-LEUKEMIA
- 1 August 1988
- journal article
- research article
- Vol. 72 (2) , 823-826
Abstract
The effects of recombinant interleukin-6 (IL-6) on the proliferation of blast precursors present in the peripheral blood of patients with acute myeloblastic leukemia (AML) was investigated. IL-6 had little effect by itself; however, it synergized with granulocyte macrophage colony-stimulating fctor (GM-CSF) and interleukin-3 (IL-3) in the stimulation of AML blast colony formation. Responsiveness of blast progenitors to IL-6 was heterogeneous. On normal bone marrow cells the same synergy was observed on granulocyte and monocyte precursors (GM-CFC), while there was no significant effect on erythroid and multipotential precursors.This publication has 12 references indexed in Scilit:
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