ADRENAL CORTICAL HORMONE LEVELS IN ADRENAL VEIN—AND PERIPHERAL BLOOD*

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Abstract
There is but little information available regarding the rate of secretion of adrenal cortical hormones, their levels in the blood and their ultimate metabolic fate. This communication deals with experiments undertaken to determine the amount of hormone in the blood of the adrenal vein and in the peripheral circulation. Inasmuch as the assay method employed was that based upon the effect of glycogen synthesis, the values obtained may be considered to indicate the levels of C-11-oxygenated-21 carbon steroids (11-oxysteroids). MATERIALS AND METHODS All blood samples, except as indicated, were obtained from trained dogs, eliminating, insofar as possible, the factors of fear and excitement as “alarming stimuli.” Peripheral arterial blood was drawn from the femoral artery, peripheral venous blood from the antecubital vein. In order to obtain blood from the adrenal vein under comparable conditions, a modified London cannula was employed. The cannula, made of vitallium, was of the type employed by Crandall (Crandall, et al. 1947);

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