The Effect of Sequential Irradiation with X-rays and Fast Neutrons on the Survival of V79 Chinese Hamster Cells

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Abstract
V79 Chinese hamster [lung] cells were exposed to X-rays or fast neutrons or to the 2 radiations given sequentially. Cells exposed to a priming dose of X-rays and then exposed immediately to a series of neutron doses regard the X-ray dose as equivalent to a neutron dose giving the same surviving the fraction (iso-effective). If the cells are exposed to a neutron dose followed by X-rays the resulting survival is higher than would be obtained if the primary dose had been an iso-effective X-ray dose. However, it is lower than would be expected if the 2 radiations acted independently. The results imply that there is interaction between the damage caused by X-rays and fast neutrons. If the 2 radiations are given 3 h apart they act independently.