In-Silico docking of HIV-1 integrase inhibitors reveals a novel drug type acting on an enzyme/DNA reaction intermediate
Open Access
- 1 January 2007
- journal article
- Published by Springer Nature in Retrovirology
- Vol. 4 (1) , 21
- https://doi.org/10.1186/1742-4690-4-21
Abstract
No abstract availableKeywords
This publication has 40 references indexed in Scilit:
- Probing HIV-1 Integrase Inhibitor Binding Sites with Position-Specific Integrase-DNA Cross-Linking AssaysMolecular Pharmacology, 2007
- A historical sketch of the discovery and development of HIV-1 integrase inhibitorsExpert Opinion on Investigational Drugs, 2006
- Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-γ binding agents with potential application to the treatment of osteoporosisBioorganic & Medicinal Chemistry Letters, 2006
- Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product releaseThe EMBO Journal, 2006
- Preliminary Mapping of a Putative Inhibitor-Binding Pocket for Human Immunodeficiency Virus Type 1 Integrase InhibitorsAntimicrobial Agents and Chemotherapy, 2006
- Molecular dynamics studies of the full-length integrase–DNA complexBiochemical and Biophysical Research Communications, 2005
- SAR and factor IXa crystal structure of a dual inhibitor of factors IXa and XaBioorganic & Medicinal Chemistry Letters, 2004
- A new test set for validating predictions of protein–ligand interactionProteins-Structure Function and Bioinformatics, 2002
- Crystal structures of the catalytic domain of HIV-1 integrase free and complexed with its metal cofactor: high level of similarity of the active site with other viral integrases 1 1Edited by R. HuberJournal of Molecular Biology, 1998
- Development and validation of a genetic algorithm for flexible docking 1 1Edited by F. E. CohenJournal of Molecular Biology, 1997