Searching for genetic determinants in the new millennium
Top Cited Papers
- 1 June 2000
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 405 (6788) , 847-856
- https://doi.org/10.1038/35015718
Abstract
Human genetics is now at a critical juncture. The molecular methods used successfully to identify the genes underlying rare mendelian syndromes are failing to find the numerous genes causing more common, familial, non-mendelian diseases. With the human genome sequence nearing completion, new opportunities are being presented for unravelling the complex genetic basis of non-mendelian disorders based on large-scale genome-wide studies. Considerable debate has arisen regarding the best approach to take. In this review I discuss these issues, together with suggestions for optimal post-genome strategies.Keywords
This publication has 33 references indexed in Scilit:
- Use of Unlinked Genetic Markers to Detect Population Stratification in Association StudiesAmerican Journal of Human Genetics, 1999
- Use of Parents, Sibs, and Unrelated Controls for Detection of Associations between Genetic Markers and DiseaseAmerican Journal of Human Genetics, 1998
- A Sibship Test for Linkage in the Presence of Association: The Sib Transmission/Disequilibrium TestAmerican Journal of Human Genetics, 1998
- Demographic history and linkage disequilibrium in human populationsNature Genetics, 1997
- Variations on a Theme: Cataloging Human DNA Sequence VariationScience, 1997
- Association Mapping of Disease Loci, by Use of a Pooled DNA Genomic ScreenAmerican Journal of Human Genetics, 1997
- The Future of Genetic Studies of Complex Human DiseasesScience, 1996
- A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosisNature Genetics, 1996
- Genetic dissection of complex traits: guidelines for interpreting and reporting linkage resultsNature Genetics, 1995
- Locating human quantitative trait loci: Guidelines for the selection of sibling pairs for genotypingBehavior Genetics, 1994