Cell surface receptor directed targeting of toxin to human malaria parasite, Plasmodium falciparum
- 28 October 1996
- journal article
- Published by Wiley in FEBS Letters
- Vol. 396 (1) , 57-61
- https://doi.org/10.1016/0014-5793(96)01065-4
Abstract
Gelonin (a toxin and type II ribosome inactivating protein) when linked to human transferrin can be targeted to Plasmodium falciparum. The transferrin toxin conjugate is significantly toxic to parasite growth and is 25 times more potent than toxin alone in inhibiting parasite protein synthesis. The mechanism of its entry into the intraerythrocytic parasite is discussed.Keywords
This publication has 35 references indexed in Scilit:
- In vivo treatment of Heymann's Nephritis using a cytotoxic protein‐toxin conjugateFEBS Letters, 1995
- Molecular genetics of drug resistance in Plasmodium faiciparum malariaParasitology Today, 1991
- Inhibition of HIV replication by pokeweed antiviral protein targeted to CD4+ cells by monoclonal antibodiesNature, 1990
- A protein on Plasmodium falciparum-infected erythrocytes functions as a transferrin receptorNature, 1986
- Immunotoxins to combat AIDSNature, 1986
- Anti-transferrin receptor monoclonal antibody and toxin–antibody conjugates affect growth of human tumour cellsNature, 1981
- Resistance of Tetrahymena to ricin, a toxic enzyme from RicinuscommunisBiochemical and Biophysical Research Communications, 1979
- Conjugation of Glucose Oxidase from Aspergillus niger and Rabbit Antibodies Using N-Hydroxysuccinimide Ester of N-(4-Carboxycyclohexylmethyl)-MaleimideEuropean Journal of Biochemistry, 1979
- Human Malaria Parasites in Continuous CultureScience, 1976
- A Method of Trace Iodination of Proteins for Immunologic StudiesInternational Archives of Allergy and Immunology, 1966