DECREASED PANCREATIC SOMATOSTATIN (SRIF) CONCENTRATION IN SPONTANEOUSLY DIABETIC MICE
- 1 November 1976
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 99 (5) , 1415-1418
- https://doi.org/10.1210/endo-99-5-1415
Abstract
Spontaneously diabetic C57BL/6J obob and C57BL/Ks dbdb mice have significantly decreased immunoassayable pancreatic somatostatin concentrations compared to lean littermate controls at 11-12 wk: obob 1.06 .+-. 0.15 pg/.mu.g protein (n = 10) vs. control 1.94 .+-. 0.26 pg/.mu.g protein (n = 10) (mean .+-. SE; P < 0.005); dbdb 0.7 .+-. 0.2 pg/.mu.g protein (n = 8) vs. control 1.5 .+-. 0.2 pg/.mu.g protein (n = 8) (mean .+-. SE; P < 0.005). An inverse relationship between circulating insulin levels and pancreatic SRIF concentration is suggested.This publication has 2 references indexed in Scilit:
- INCREASED SOMATOSTATIN CONTENT OF ISLETS FROM STREPTOZOTOCIN‐DIABETIC RATSClinical Endocrinology, 1976
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951