EFFECTS OF ALLOXAN INBIRDS

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Abstract
Barn owls, horned owls, pigeons, ducks and chickens were injected intravenously with alloxan in doses varying from 50 to 400 mg./kg., and in some cases repeatedly at various intervals. Only pigeons, showed a change in blood sugar in excess of normal variations. These piegons died in 1-2 days after a single injn. Microscopic study of pancreatic tissue showed no change or minimal changes of the [beta] cells. In some instances deposition of a crystalline material was observed on the serosal surfaces and in the kidneys. This may have been responsible for death in these cases. No pathologic changes were observed in the other birds which died following alloxan injns.

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