Wound sepsis after low risk elective cholecystectomy: The effect of cefuroxime
- 1 July 1984
- journal article
- clinical trial
- Published by Oxford University Press (OUP) in British Journal of Surgery
- Vol. 71 (7) , 540-542
- https://doi.org/10.1002/bjs.1800710724
Abstract
A prospective randomized double-blind study was performed to assess the value of a single intravenous injection of 1·5 g cefuroxime in the prevention of wound sepsis after low risk elective cholecystectomy. Wound infection developed in 10 of 81 control patients compared with 2 of 79 treated patients (P < 0·05). Wound sepsis occurred more commonly in patients with infected bile or with a positive culture from a closing wound swab. Cefuroxime significantly reduced the isolation of staphylococci but not other organisms from the closing wound swab and also produced a significant reduction in wound infection in patients with sterile bile.Keywords
Funding Information
- Scottish Hospital Endowments Research Trust
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