DISTRIBUTION OF [PREDNISOLONE-H-3 ENTRAPPED IN LIPID LAYER OF LIPOSOME AFTER INTRAMUSCULAR ADMINISTRATION IN RATS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 24  (2) , 223-232
Abstract
Positively charged, sonicated liposome entrapping [3H]prednisolone was administered into rat hip muscle to study its absorption and distribution in comparison with that of free [3H]prednisolone. Plasma concentration of prednisolone in liposome-entrapped form showed high concentration for a long period of time; the values were 8 times higher after 30 min and 24 times higher after 24 h compared to the free form. The concentration of liposome-entrapped form in liver, kidney and spleen was 4-10 times higher and in lung and pancreas 8-10 times higher than that of free form after 30 min and 24 h. In adrenal, after 30 min and 1 h, the concentration of the liposome-entrapped form was lower than that of free form; the former remained longer in the tissue and the concentration maintained the high level after 24 h, about 28 times higher than that of free form. In the duodenum and large intestine, absorption of the liposome-entrapped form was very active and remained in the tissue for a long period of time. It is possible to administer a small i.m. dose and allow the steroid to remain in the tissues for a long period of time.