Splanchnic Turn‐over of Some Energy Metabolites and Acid‐Base Balance during Intravenous Infusion of Lidocaine, Bupivacaine or Etidocaine

Publisher Website
Google Scholar
Abstract
The splanchnic turn‐over of energy metabolites in circulating blood has been studied in four groups of young, healthy volunteers, receiving intravenous infusions of physiological saline (n = 5), lidocaine 4 mg/min (n = 7), bupivacaine 2 mg/min (n = 7) and etidocaine 2 mg/min (n = 8). The results showed that the local anaesthetic agents increased the splanchnic blood flow and oxygen consumption, the uptake of glycerol and lactate, and the release of 3‐hydroxybutyrate. These effects are adrenaline‐like but cannot be explained by one single mechanism involving increased activity of the sympathetic nervous system. Only a minor part of the increased oxygen uptake could be attributed to the energy cost of drug metabolism.