Derivatives of 1-hydroxy-3-aminopyrrolidin-2-one (HA-966). Partial agonists at the glycine site of the NMDA receptor
- 1 January 1993
- journal article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 3 (1) , 71-76
- https://doi.org/10.1016/s0960-894x(00)80094-3
Abstract
No abstract availableKeywords
This publication has 16 references indexed in Scilit:
- Routes to 4-substituted analogues of the glycine/NMDA antagonist HA-996. Enantioselective synthesis of (3R,4R) 3-amino-1-hydroxy-4-methyl-2-pyrrolidinone (L-687, 414).Tetrahedron, 1992
- The glycine-site NMDA receptor antagonist, R-(+)− cis-β-methyl-3-amino-1-hydroxypyrrolid-2-one, L-687, 414 is anticonvulsant in baboonsEuropean Journal of Pharmacology, 1992
- In Vivo Distribution of CGS-19755 Within Brain in a Model of Focal Cerebral IschemiaJournal of Neurochemistry, 1992
- Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptorJournal of Medicinal Chemistry, 1991
- Effects of NG‐nitro‐l‐arginine methyl ester or indomethacin on differential regional and cardiac haemodynamic actions of arginine vasopressin and lysine vasopressin in conscious ratsBritish Journal of Pharmacology, 1991
- The discriminative stimulus properties of (+)-HA-966, an antagonist at the glycine/N-methyl-D-aspartate receptorEuropean Journal of Pharmacology, 1990
- Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative.Proceedings of the National Academy of Sciences, 1990
- The behavioural effects of MK-801: a comparison with antagonists acting non-competitively and competitively at the NMDA receptorEuropean Journal of Pharmacology, 1989
- HA-966 antagonizes N-methyl-D-aspartate receptors through a selective interaction with the glycine modulatory siteJournal of Neuroscience, 1989
- Resolution and synthesis of the individual enantiomers of the glycine antagonist 3-amino-1-hydroxypyrrolidin-2-one (HA-966)Journal of the Chemical Society, Chemical Communications, 1989