Inhibitory Effects of Thiopental, Ketamine, and Propofol on Voltage-dependent Calcium sup 2+ Channels in Porcine Tracheal Smooth Muscle Cells
Open Access
- 1 December 1995
- journal article
- laboratory investigation
- Published by Wolters Kluwer Health in Anesthesiology
- Vol. 83 (6) , 1274-1282
- https://doi.org/10.1097/00000542-199512000-00018
Abstract
Background: Intravenously administered anesthetics directly inhibit airway smooth muscle contraction. Because many anesthetic agents affect membrane ion channel function and sustained contraction of airway smooth muscle requires the influx of Calcium2+ through voltage-dependent Calcium2+ channels, it was hypothesized that intravenous anesthetics inhibit airway smooth muscle voltage-dependent Calcium2+ channels.Keywords
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