Cryptic stage of sleeping-sickness trypanosome developing in choroid plexus epithelial cells.
- 13 November 1982
- Vol. 285 (6352) , 1380-1382
- https://doi.org/10.1136/bmj.285.6352.1380
Abstract
Electronmicrographs of the choroid plexus from rats infected with Trypanosoma brucei rhodesiense showed that trypomastigotes from the perivascular spaces may penetrate and undergo multiple division in the ependymal cells which locally constitute the blood-brain barrier. Progressive degeneration of the ependymal cell liberates trypomastigotes back into the perivascular space, from which re-entry into the blood may occur. Re-entry to the blood does not take place from any tissues other than the brain and its membranes. These findings suggest that the ependymal cells of the choroid plexus are the site of the cryptic stage of the sleeping-sickness trypanosome.This publication has 13 references indexed in Scilit:
- Light and electron microscope studies on extravascular Trypanosoma brucei gambiense in the brain of chronically infected rodents.1981
- Pleomorphism and the problem of recrudescent parasitaemia following treatment with salicylhydroxamic acid (SHAM) in African trypanosomiasisTransactions of the Royal Society of Tropical Medicine and Hygiene, 1980
- The brain as a source of relapsing Trypanosoma brucei infection in mice after chemotherapyInternational Journal for Parasitology, 1979
- Trypanosoma brucei: miniature anion-exchange centrifugation technique for detection of low parasitaemias: adaptation for field useTransactions of the Royal Society of Tropical Medicine and Hygiene, 1979
- Identification of the trypanocidal factor in normal human serum: high density lipoprotein.Proceedings of the National Academy of Sciences, 1978
- Trypanosomiasis: An Approach to Chemotherapy by the Inhibition of Carbohydrate CatabolismScience, 1976
- Penetration of mid-gut cells of Glossina morsitans morsitans by Trypanosoma brucei rhodesienseNature, 1975
- Simultaneous presence of different antigenic populations of Trypanosoma brucei gambiense in Microtus montanusParasitology, 1973
- An amastigote phase of the sleeping sickness trypanosomeTransactions of the Royal Society of Tropical Medicine and Hygiene, 1971