Risk Stratification in the Long-QT Syndrome
Top Cited Papers
- 8 May 2003
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 348 (19) , 1866-1874
- https://doi.org/10.1056/nejmoa022147
Abstract
Mutations in potassium-channel genes KCNQ1 (LQT1 locus) and KCNH2 (LQT2 locus) and the sodium-channel gene SCN5A (LQT3 locus) are the most common causes of the long-QT syndrome. We stratified risk according to the genotype, in conjunction with other clinical variables such as sex and the length of the QT interval.Keywords
This publication has 16 references indexed in Scilit:
- Molecular and Cellular Mechanisms of Cardiac ArrhythmiasCell, 2001
- Genotype-Phenotype Correlation in the Long-QT SyndromeCirculation, 2001
- Spectrum of Mutations in Long-QT Syndrome GenesCirculation, 2000
- Genetic and Molecular Basis of Cardiac Arrhythmias: Impact on Clinical Management Parts I and IICirculation, 1999
- Low Penetrance in the Long-QT SyndromeCirculation, 1999
- Influence of the Genotype on the Clinical Course of the Long-QT SyndromeNew England Journal of Medicine, 1998
- Age- and Sex-Related Differences in Clinical Manifestations in Patients With Congenital Long-QT SyndromeCirculation, 1998
- Long QT Syndrome Patients With Mutations of the SCN5A and HERG Genes Have Differential Responses to Na + Channel Blockade and to Increases in Heart RateCirculation, 1995
- ECG T-Wave Patterns in Genetically Distinct Forms of the Hereditary Long QT SyndromeCirculation, 1995
- The idiopathic long QT syndrome: the need for a prospective registryEuropean Heart Journal, 1983