Selective deficiency of cytotoxic B lymphocytes in man.
- 1 September 1972
- journal article
- Vol. 12 (1) , 1-8
Abstract
A patient is described with macroglobulinaemia, a variety of autoantibodies, and gross deficiency of lymphocytes showing cytotoxicity against antibody-sensitized target cells in vitro. Antibody production in response to tetanus toxoid, delayed hypersensitivity to tuberculin, and lymphocyte transformation with phytohaemagglutinin are normal. The patient's macrophages have normal phagocytic activity against sensitized sheep red cells. These results are contrasted with those found in other patients with myeloma and macroglobulinaemia. The application of lymphocyte function tests in the assessment of immunological status is discussed.This publication has 10 references indexed in Scilit:
- In vitro cytotoxicity of lymphocytes from patients with "acquired" and sex-linked agammaglobulinaemia.1971
- Cytotoxic Lymphocytes from Rats depleted of Thymus Processed CellsNature New Biology, 1971
- The establishment of a normal human population dose-response curve for lymphocytes cultured with PHA (phytohaemagglutinin).1971
- The thymus and circulating lymphocytes of miceProceedings of the Royal Society of London. B. Biological Sciences, 1970
- INDUCTION OF CYTOTOXICITY OF LYMPHOCYTES FROM TOLERANT DONORS BY ANTIBODIES TO TARGET CELL ALLOANTIGENSTransplantation, 1970
- Failure of Certain Cytotoxic Lymphocytes to respond mitotically to PhytohaemagglutininNature, 1970
- Purification of lymphocytes and platelets by gradient centrifugation.1968
- Impaired phytohaemagglutinin-induced cytotoxicity in vitro of lymphocytes from patients with Hodgkin's disease or chronic lymphatic leukaemia.1967
- Contact-Induced Cytotoxicity by Lymphoid Cells Containing Foreign IsoantigensScience, 1965
- Tetanus antitoxin titration by haemagglutinationEpidemiology and Infection, 1957