The Effect of β-Turn Structure on the Passive Diffusion of Peptides Across Caco-2 Cell Monolayers
- 1 January 1997
- journal article
- research article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 14 (10) , 1332-1340
- https://doi.org/10.1023/a:1012152117703
Abstract
Purpose. To investigate the relationships between the β-turn structure of a peptide and its passive diffusion across Caco-2 cell monolayers, an in vitro model of the intestinal mucosa. Methods....Keywords
This publication has 13 references indexed in Scilit:
- Effect of Restricted Conformational Flexibility on the Permeation of Model Hexapeptides Across Caco-2 Cell MonolayersPharmaceutical Research, 1997
- Effect of Size and Charge on the Passive Diffusion of Peptides Across Caco-2 Cell Monolayers via the Paracellular PathwayPharmaceutical Research, 1997
- Esterase-Sensitive Cyclic Prodrugs of Peptides: Evaluation of a Phenylpropionic Acid Promoiety in a Model HexapeptidePharmaceutical Research, 1997
- Esterase-Sensitive Cyclic Prodrugs of Peptides: Evaluation of an Acyloxyalkoxy Promoiety in a Model HexapeptidePharmaceutical Research, 1996
- Quantitative Approaches To Delineate Paracellular Diffusion in Cultured Epithelial Cell MonolayersJournal of Pharmaceutical Sciences, 1994
- Mechanism of Intestinal Absorption of Ranitidine and Ondansetron: Transport Across Caco-2 Cell MonolayersPharmaceutical Research, 1993
- Peptide secondary structure induced by a micellar phospholipidic interface: proton NMR conformational study of a lipopeptideBiochemistry, 1992
- Epithelial Transport of Drugs in Cell Culture. II: Effect of Extracellular Calcium Concentration on the Paracellular Transport of Drugs of Different Lipophilicities across Monolayers of Intestinal Epithelial (Caco-2) CellsJournal of Pharmaceutical Sciences, 1990
- Transferred nuclear Overhauser effect analyses of membrane-bound enkephalin analogs by proton nuclear magnetic resonance: correlation between activities and membrane-bound conformationsBiochemistry, 1990
- Folding of immunogenic peptide fragments of proteins in water solutionJournal of Molecular Biology, 1988